黑帮老大艾迪?金策划了一起凶杀案，被偶然路过的年轻人西恩?琼斯（Nathan Phillips 饰）目击。为了在法庭上成功指控这个作恶多端的黑社会头子，警方派出资深联邦密探尼维利?费恩（Samuel L. Jackson 饰）负责保护西恩，并将其从夏威夷护送至洛杉矶法庭。为避免证人遇害，尼维利采取声东击西的策略，与西恩偷偷乘上一架普通的红眼航班。 　　然而这项绝密的计划被艾迪安排在警方的内奸获知，为了逃脱法律制裁，艾迪派出携带大量毒蛇的杀手登上飞机，一场离奇恐怖的血腥灭口案件就此展开……

莉拉·邓恩在密苏里州一个陌生的小镇买了一栋房子，却发现了一本与失踪钻石有关的日记。然而，另有人正在追捕这颗钻石，并为此不惜杀人。当她的第一位客人到来时，刺客们便紧随其后。现在，她必须奋力保护家园，求生自救。—亚伦·L·威廉姆斯

　　影片根据1993年同名射击游戏改编而成。
　　2145年火星舰队总部接到从该地区传来的微弱求救信号，而在那里科学探测站正在进行着遗传密码破解的重要实验，一旦该地区失去控制，无疑将会造成整个人类的一场大劫难。特别行动队队长瑞博尔（卡尔·厄本 Karl Urban 饰）、士官长萨吉（道恩·强森 Dwayne Johnson 饰）带着六名队员迅速登陆以救援基地内的幸存者，可当他们进入基地时，发现实验室不仅一片狼藉，而且实验室里满是怪物。更可怕的是，这些行为怪异的生物并非来自外星，而是受到某种未知病毒感染后的人类！面对随时可能被感染的危险，萨吉必须和他的队员们利用手中的每一件武器，深入到实验室中心，找出真相，完成他们的使命。RRTSRTS惟一可以做的是把通往地球的通道用免疫隔离系统封锁，再背水一战，用尽身上每一件终极武器，将这班魔怪一一歼灭……

　　A group of tired commuters have caught the last train home, ready to hop into their beds for the night. However, their train soon veers off-course and crashes into an abandoned tunnel. The three surviving commuters; withdrawn mother Yi Ling, her son Lucas, and student Janice, are forced to band together and survive the night, as well as avoid the mysterious monster hunting them. Yi Ling still suffers from flashbacks to the car accident that killed her husband and nearly took Lucas` life too. When Lucas is snatched away by the monster, her maternal instincts are tested, and Janice`s ideas of family are challenged as she remembers her difficult relationship with her estranged father. Back at the subway control headquarters, the engineers do their best to make sense of the situation and rescue the survivors.

　　Follows Iraqi war veteran Tes, as she prepares to strike back after a group of home invaders attack during her sister's bachelorette party, and she discovers that they are hellbent on not leaving any witnesses behind.